气候变化健康风险评估、环境毒理学

1. 中国博士后科学基金第75批面上项目，基于多组学的极端温度和PM2.5复合暴露对哮喘影响机制和预测预警研究，2024-07至2025-06，8万，结题，主持

2. 2024年度国家资助博士后研究人员计划C档项目，高温臭氧复合暴露对慢性阻塞性肺疾病的协同效应和作用机制研究，2024-07至2025-06，24万，结题，主持

3. 国家自然科学基金委员会，面上项目，82070458，外泌体在介导大气细颗粒物暴露导致内皮细胞损伤及平滑肌细胞表型转化中的分子机制研究，2021-01-01 至 2024-12-31，55万元，结题，参与

1. Jiayu Xu, Qiong Wang, Olga Anikeeva, Peng Zhu, Peng Bi, Cunrui Huang*. Effects of extreme heat on physiology, morbidity, and mortality under climate change: mechanisms and clinical implications. BMJ. 2025 Oct 29;391:e084675.

2. Jiayu Xu, Guogang Xu, Zehua Liu, Zhao Ma, Liangliang Cheng, Ruoyu Hou, John S. Ji, Cunrui Huang*. COPD risk due to extreme temperature exposure: combining epidemiological evidence with pathophysiological mechanisms. eBioMedicine, 2025 Apr 30;116:105731.

3. Jiayu Xu, Qiaojian Zhang, Zekang Su, Yu Liu, Tenglong Yan, Yali Zhang, Changmao Long, Tiancheng Wang, Xuetao Wei, Zhangjian Chen, Guiping Hu, Tian Chen, Guang Jia*. Genetic damage and potential mechanism exploration under different air pollution patterns by multi-omics, Environment International, 2022 Dec 19;170:107636.

4. Jiayu Xu, Yu Liu, Qiaojian Zhang, Zekang Su, Tenglong Yan, Shupei Zhou, Tiancheng Wang, Xuetao Wei, Zhangjian Chen, Guiping Hu, Chen Tian, Guang Jia*. DNA damage, serum metabolomic alteration and carcinogenic risk associated with low-level air pollution，Environmental Pollution, 2022 Mar 15; 297:118763.

5. Jiayu Xu, Zekang Su, Yuxuan Nie, Muyi Sun, Yanfeng Zhu, Jing Zeng, Qian Bu, Qin Zhou, Jing Nie, Yifan Shi, Jinglong Zhang, Feifei Liu, Zhiping Niu*. Impact of PM2.5 components on lung function deterioration and the modifying effects of systemic inflammation in chronic lung disease patients. Ecotoxicol Environ Saf. 2025 Oct 15;305:119197.

6. Jiayu Xu#, Jiaying Li#, Jiaqi Wang, Shourui Huang, Beilei Wang, Liangliang Cui* , Xiang Ma*. The effects of temperature variation on obstructive pulmonary dysfunction and small airway dysfunction in asthmatic children: A continuous eight-year study in Jinan, China. Environmental Research, 2025 Feb 11; 272:121096.

7. Jiayu Xu, Zekang Su, Chenchen Liu, Yuxuan Nie, Liangliang Cui. Climate change, air pollution and chronic respiratory diseases: understanding risk factors and the need for adaptive strategies. Environmental Health and Preventive Medicine, 2025;30:7.

8. Jiayu Xu, Jingwen Zhou, Zhangjian Chen, Xiumiao Peng, Zhong Liu, Liangliang Cui*. Temporal characterization, carcinogenic risk assessment and meteorological effects of ambient polycyclic aromatic hydrocarbons in Jinan city. International Journal of Environmental Research, 2022 Aug 15; 16:55.

9. Jingxiao Shang#, Jiayu Xu#, Tianqin Xie, Xiaoming Tang, Jing Wang, Ting Wang, Yuewei Liu, Daomin Zhu, and Cunrui Huang*. The mediating role of thyroid hormone in the association between heatwave exposure and depression severity, Environment International, 2025 May 8; 200:109523.

10. Zihua Zhong#, Jiayu Xu#, Zehua Liu, Xiaoming Tang, Jiajia Zhang, Tianqin Xie, Yuewei Liu, Cunrui Huang*, Daomin Zhu*, Jing Wang *. The impact of different types of extreme temperature events on mental disorders: A case-crossover Study in Anhui Province, China. Environmental Research, 2025 Apr 1;277:121526.